Bound and free fraction
A carrier-bound bar holds most of the hormone while the small free active bar beneath trades length with it across the equilibrium, the total bracket above staying fixed.
CSS
Endocrine
15 animationsCircadian entrainment
A phase hand makes one turn of a twenty-four hour dial, the high-phase arc holding full weight while the hand is inside it and the entrainment mark lighting as the hand returns to it.
CSSDose response
A sigmoid response curve draws out as the dose marker walks along the axis, and the half-maximal tick lights as the curve crosses it.
CSSExogenous suppression
Across three dose steps the supplied share of each stacked column grows and the endogenous share below it falls by the same amount, holding every column top on the set-point rule.
CSSFeedback inhibition
An output level climbs on a plotted trace until a return arm closes back onto its own source, and the source's output damps down toward the set-point rule.
CSSFree-running drift
With the entraining marker withdrawn, successive rhythm rows on a stacked raster slip later against a fixed reference rule and build a drift staircase.
CSSHormone axis
A releasing pulse steps down three stacked rails and the output bar at each tier grows taller than the one above it, showing the axis amplifying as it descends.
CSSHormone clearance
A bolus lifts the level to peak and an exponential decay trace runs down across half-life gridlines, each halving marker lighting as the trace reaches it.
CSSPositive feedback surge
Successive output columns accelerate left to right and run away past a tipping rule, the rule brightening once the surge has crossed it.
CSSPulsatile secretion
A train of secretory pulses spreads apart and closes again at constant height, the rate bar beneath tracking the change so frequency rather than amplitude carries the message.
CSSReceptor blockade
A blocker sits in the binding pocket and holds it, the arriving agonist is turned aside along a dashed deflection path and the response bar beneath reads zero.
CSSReceptor downregulation
The input level holds flat and high while the receptor sites in the strip below go out one by one and the response level falls away from its expected rule.
CSSReceptor occupancy
Ligands arrive at a row of receptor sites and fill them one after another, the occupancy bar beneath tracking the fraction bound before they release.
CSSSet point regulation
A level oscillates about a dashed set-point rule with the swings shrinking cycle by cycle until the trace sits inside the tolerance band.
CSSThreshold release
A stimulus level rises to a dashed threshold rule, crosses it, and the output channel below fires one discrete burst before the level falls back to floor.
CSS