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A notched substrate seats into the matching enzyme cleft, splits into two products that ride out along the rail, and a fresh substrate walks in behind it.
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Biochem
15 animationsAllosteric switch
An effector seats in the remote regulatory slot, a pulse runs along the coupling, and the distant catalytic cleft swings open in response.
CSSATP cycle
The terminal phosphate leaves the chain along the transfer route, charges the acceptor, and returns to refill the dashed slot it left behind.
CSSBuffer capacity
Four equal acid additions land in turn: the first three barely move the pH trace inside the band, and the fourth takes it straight out the bottom.
CSSChaperone chamber
The lid lifts and a finished native fold leaves the chamber, a slack chain enters behind it, and the lid drops while the refold happens inside.
CSSCompetitive inhibitor
A round plug occupies the mouth of the wedge socket, so the correctly keyed substrate runs up the lane, fails to seat and backs off.
CSSDenaturation
The temperature column climbs past the melting rule and the tight native coil runs out flat and slack, re-forming only once the column falls back.
CSSFeedback inhibition
The product tank refills once the gate lifts, and at the trigger level a signal runs back along the return arc and drops the gate on the first step again.
CSSInduced fit
The two jaws of an enzyme cleft close in around the ligand that has arrived, gripping it, then relax back to the open geometry marked by the faint rules.
CSSMetabolic pathway
Metabolites step through four enzyme stations along the rail and queue two deep in front of the narrow committed step, passing through it one at a time.
CSSProtein folding
Six residues laid out along the extended rail collapse onto a compact native core, the rail fading as the core envelope closes around them.
CSSProton gradient
A proton runs the crowded face of the membrane to the pore and drops through it, indexing the rotor one third of a turn on every crossing.
CSSProtonation state
A pH slider walks past the pKa rule and the side chain releases its proton, the charge badge appearing as it goes and clearing when the slider returns.
CSSSaturation curve
A rate-versus-substrate trace runs out from the origin and stalls against the Vmax asymptote, with a Km rule standing at the half-maximal point.
CSSTurnover
A token steps round the catalytic cycle from station to station, holding at each, and releases a product down the drain on the release step.
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